Abstract
Cutaneotrichosporon oleaginosus is an oleaginous yeast with several favourable qualities: It is fast growing, accumulates high amounts of lipids and has a very broad substrate spectrum. Its resistance to hydrolysis by-products makes it a promising biocatalyst for custom tailored microbial oils. C. oleaginosus can accumulate up to 60 wt.% of its biomass as lipids. This species is able to grow by using several compounds as a substrate, such as acetic acid, biodiesel-derived glycerol, N-acetylglucosamine, lignocellulosic hydrolysates, wastepaper and other agro-industrial wastes. This review is focused on state-of-the-art innovative and sustainable biorefinery schemes involving this promising yeast and second- and third-generation biomasses. Moreover, this review offers a comprehensive and updated summary of process strategies, biomass pretreatments and fermentation conditions for enhancing lipid production by C. oleaginosus as a whole-cell biocatalyst. Finally, an overview of the main industrial applications of single-cell oil is reported together with future perspectives.
Highlights
The transition from a linear fossil-based economy to a new circular biobased one is a current global goal that requires the replacement of traditional refineries with innovative and sustainable biorefineries
This yeast can grow on carbon-rich media obtained from lignocellulosic biomasses [17], organic acids [31], organic wastes from the agriculture and food industry [32] as well as active sludge [33]
To other review works related to other species of oleaginous yeasts [36], the present review summarises, for the first time, recent biorefinery approaches involving the whole-cell biocatalyst C. oleaginosus (Figure 1)
Summary
The transition from a linear fossil-based economy to a new circular biobased one is a current global goal that requires the replacement of traditional refineries with innovative and sustainable biorefineries. C. oleaginosus is fast growing, is able to use a wide range of carbon sources, can accumulate a high content of TAGs (up to 60% of its dry cell weight) [27] and presents good tolerance to the main growth inhibitors This yeast can grow on carbon-rich media obtained from lignocellulosic biomasses [17], organic acids [31], organic wastes from the agriculture and food industry [32] as well as active sludge [33]. It is well studied, there is no updated review regarding its use for the production of SCOs in the literature up to now For this reason, to other review works related to other species of oleaginous yeasts [36], the present review summarises, for the first time, recent biorefinery approaches involving the whole-cell biocatalyst C. oleaginosus (Figure 1). Finery models based on the principles of Green Chemistry and the Circular Economy
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