Cut Off Point of Telomere Length and Association With Blood Glucose and Lipid Profile Among Minangkabau Ethnic Women

Abstract

The aim of this study to determine the cutoff point of telomere length and association with blood glucose and lipid profile among Minangkabau ethnic women. This cross-sectional study was conducted in Padang City, Indonesia using a sample of 116 Minangkabau ethnicity women aged between 40-55 years. The blood sample analysis using O’Callaghan and Fenech's technique to measure telomere length, fasting blood glucose and lipid profile analysis from blood venous. Data analysis using Pearson correlation and then continued for known cut off point by Hosmer-Lemeshow test. Data were processed using Stata version 14.2 (Stata Corporation). The results showed there is no correlation between blood glucose and profile lipid (total cholesterol, LDL, HDL, and triglycerides) with telomere length of Minangkabau ethnicity women (p>0.05). Based on receiver operating characteristic (ROC) curve analysis, we obtained a cutoff point for telomere length is 385 bp with 53% sensitivity, 55% specificity and an accuracy of 58.2%. Blood glucose and lipid profile do not have correlation because of telomere length cause of many factors. This analysis confirmed there is no correlation blood glucose and profile lipid with telomere length of Minangkabau ethnicity women. Cut off point for predicted telomere length is 385 bp.