Abstract
The intrinsic architecture of tissues and engineered scaffolds subject cells to geometrical cues in the form of mesoscale curvatures. While the effect of nano- and micro-scale topographical cues have been extensively studied for decades, surprisingly little is known about the cell response to non-planar geometries larger than cell size. To study the effect of curvature in a systematic and high-throughput manner, we developed a microfabricated chip containing arrays of concave and convex structures with a wide range of types and sizes (μm to mm) and investigated cell migration behavior on these structures.
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