Curvature-based lipid partitioning and localization in a mitochondrial inner membrane model

Abstract

Membrane curvature takes on distinct forms in various biological membranes and is actively modulated in various cellular processes. Lipid composition and asymmetry across bilayer leaflets are factors responsible for regulating and maintaining the curvature of biological membranes. Mitochondrial membranes are unique structures and are composed of an inner and outer mitochondrial membrane with a significant concentration of cardiolipin (CDL) lipids. CDL is only found in low abundance in other eukaryotic membranes and is considered the signature lipid of the mitochondria.