Abstract
The presented review concerns contemporary views on specific aspects of anticoagulant and thrombolytic treatment of venous thromboembolism and mostly of acute pulmonary embolism. Modern classifications of patients with acute pulmonary embolism, based on early mortality risk and severity of thromboembolic event, are reproduced. The importance of multidisciplinary approach to the management of patients with pulmonary embolism with the assistance of cardiologist, intensive care specialist, pulmonologist, thoracic and cardiovascular surgeon, aimed at the management of pulmonary embolism at all stages: from clinical suspicion to the selection and performing of any medical intervention, is emphasized. Anticoagulant treatment with the demonstration of results of major trials, devoted to efficacy and safety evaluation of anticoagulants, is highlighted in details. Moreover, characteristics, basic dosage and dosage scheme of direct (new) oral anticoagulants, including apixaban, rivaroxaban, dabigatran, edoxaban and betrixaban are described in the article. In particular, the management of patients with bleeding complications of anticoagulant treatment and its application in cancer patients, who often have venous thromboembolism, is described. Additionally, modern approaches to systemic thrombolysis with intravenous streptokinase, urokinase and tissue plasminogen activators are presented in this review. The indications, contraindications, results of clinical trials devoted to various regimens of thrombolytic therapy, including treatment of pulmonary embolism by lower doses of fibrinolytic agents, are described.
Highlights
Characteristics, basic dosage and dosage scheme of direct oral anticoagulants, including apixaban, rivaroxaban, dabigatran, edoxaban and betrixaban are described in the article
The indications, contraindications, results of clinical trials devoted to various regimens of thrombolytic therapy, including treatment of pulmonary embolism by lower doses of fibrinolytic agents, are described
Classification of patients with acute pulmonary embolism based on early mortality risk
Summary
М. Горького», Донецк, Украина 2 — ГУ «Институт неотложной и восстановительной хирургии им. СОВРЕМЕННЫЕ ВЗГЛЯДЫ НА АНТИКОАГУЛЯНТНУЮ И ТРОМБОЛИТИЧЕСКУЮ ТЕРАПИЮ ОСТРОЙ ЛЕГОЧНОЙ ЭМБОЛИИ. 1− State Educational Organization of Higher Professional Education «M. Gorky Donetsk National Medical University», Donetsk, Ukraine 2 − State Institution «V.K. Gusak Institute of Urgent and Recovery Surgery», Donetsk, Ukraine. Представленный обзор посвящен современным представлениям об особенностях антикоагулянтной и тромболитической терапии венозной тромбоэмболии и, в большей степени, острой легочной эмболии. Приводится современная классификация больных с острой легочной эмболией на основе расчёта риска ранней смертности и массивности тромбоэмбологенного события. Подробно освещена антикоагулянтная терапия с демонстрацией результатов крупных исследований, посвященных оценке эффективности и безопасности антикоагулянтных препаратов. Описываются показания, противопоказания, результаты клинических исследований, посвященных различным режимам тромболитической терапии, включая лечение легочной эмболии пониженными дозировками фибринолитиков. Ключевые слова: легочная эмболия, венозная тромбоэмболия, тромбоэмболия легочной артерии, лечение, стратификация риска, антикоагулянтная терапия, прямые оральные антикоагулянты, системный тромболизис, фибринолиз, геморрагические осложнения
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
