Abstract
Biological variation (BV) is intertwined with many considerations in laboratory medicine and forms a basis for setting analytical performance specifications, delta check parameters, reference intervals, and reference change values. Biological variation describes the fluctuation in analyte concentration around a homeostatic setpoint within a single subject (within-subject BV) or a group of subjects (between-subject BV). Literature evaluating BV data in laboratory medicine stretches back over 50 years; however, the lack of standardization and appropriate study designs to derive BV data has led to significant discrepancy in reported BV estimates. This lack of reproducibility in older BV studies significantly hindered its adoption into clinical practice.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
