Current Understating of Gut Microbiome Alterations and Therapeutic Approaches for Improving Human Health

Abstract

Millions of microorganisms, including bacteria, fungi, and viruses compose the human gut microbiome. There is variation in the composition of species from the moment of birth throughout the whole human lifecycle. Gut microbiome play a central role in maintaining body equilibrium, influencing a range of physiological processes including metabolism, the maintenance of barriers, inflammation, and hematopoiesis, both within and outside the intestines. An imbalanced microbial environment within the gastrointestinal tract is at the core of numerous diseases, such as inflammatory bowel disorder, obesity, diabetes, and Clostridioides difficile infection, and plays a pivotal role in their development. In this review, we discuss the therapeutic approaches of gut microbiome-related therapies including fecal microbiota transplantation, anti-microbial therapies, prebiotics, probiotics and Dietary interventions to repair the altered gut microbiome composition. The pursuit of new therapies and their subsequent improvement is propelled by an ongoing requirement for evaluation, experimentation, laboratory procedures, and the ethical and technological limitations associated with clinical translation.