Abstract
Systemic lupus erythematosus (SLE) is a common and potentially fatal autoimmune disease that affects multiple organs. To date, its etiology and pathogenesis remains elusive. Circular RNAs (circRNAs) are a novel class of endogenous non-coding RNAs with covalently closed loop structure. Growing evidence has demonstrated that circRNAs may play an essential role in regulation of gene expression and transcription by acting as microRNA (miRNA) sponges, impacting cell survival and proliferation by interacting with RNA binding proteins (RBPs), and strengthening mRNA stability by forming RNA-protein complexes duplex structures. The expression patterns of circRNAs exhibit tissue-specific and pathogenesis-related manner. CircRNAs have implicated in the development of multiple autoimmune diseases, including SLE. In this review, we summarize the characteristics, biogenesis, and potential functions of circRNAs, its impact on immune responses and highlight current understanding of circRNAs in the pathogenesis of SLE.
Highlights
Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune disease characterized by production of multiple autoantibodies and involvement of multi-systemic organ damage [1]
It has been proposed that the competing endogenous RNAs including pseudogenes and long-chain non-coding RNA can act as sponges for miRNAs through their binding sites of miRNA recognition elements (MREs) [41,42,43]
By microarray analysis of circRNA expression profile in neutrophils derived from patients with asymptomatic moyamoya disease (MMD) and healthy individuals, 123 differentially expressed circRNAs were identified between the two groups
Summary
Edited by: Philippe Saas, INSERM U1098 Interactions HoteGreffon-Tumeur & Ingenierie Cellulaire et Genique, France. Systemic lupus erythematosus (SLE) is a common and potentially fatal autoimmune disease that affects multiple organs. Circular RNAs (circRNAs) are a novel class of endogenous non-coding RNAs with covalently closed loop structure. Growing evidence has demonstrated that circRNAs may play an essential role in regulation of gene expression and transcription by acting as microRNA (miRNA) sponges, impacting cell survival and proliferation by interacting with RNA binding proteins (RBPs), and strengthening mRNA stability by forming RNA-protein complexes duplex structures. The expression patterns of circRNAs exhibit tissue-specific and pathogenesis-related manner. CircRNAs have implicated in the development of multiple autoimmune diseases, including SLE. We summarize the characteristics, biogenesis, and potential functions of circRNAs, its impact on immune responses and highlight current understanding of circRNAs in the pathogenesis of SLE
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