Abstract

Tuberculosis (TB) is regarded as one of the highly infectious diseases which is caused by the species of Mycobacterium genus. Tuberculosis forms to be a major public health issue worldwide because it is anti-drug resistant; extensively drug-resistant (XDR) TB and multidrug-resistant (MDR) TB. Thus, there is an exigent need for the development of new anti-TB drugs. Various drugs are developed in the treatment of different ailments including chronic and TB related symptoms. The present study focuses on the evolution of drug resistance in Mycobacterium tuberculosis, the virulence of Mycobacterium tuberculosis, and preparation of model for evaluation of virulence caused by Mycobacterium tuberculosis. Efforts are also made to summarize the drug resistance mechanism in Mycobacterium tuberculosis including intrinsic and acquired drug resistance.

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