Abstract
The rational use of antibiotics in the treatment of orthopedic infection still presents a significant problem. Local antibiotic delivery systems enable to achieve effective concentrations of drugs in the focus of bone infection without the development of toxicity. It is the important accompaniment to systemic antibiotics in the treatment of periprosthetic infection and osteomyelitis. The data collected through the PubMed and eLIBRARY databases (http://www.ncbi.nlm. nih.gov/pubmed, 1995-2015; http://elibrary.ru, 2005-2015 years) present the information about bone substitutes used for local antibiotic therapy in scientific investigations and in clinical practice. The information is submitted in accordance with the groups of materials: cements based on polymethylmethacrylate, bone grafts, demineralized bone matrix, bioceramics, natural and synthetic polymers, combined antibiotic delivery systems. The majority of these materials have only been studied experimentally and only a limited range of them is registered for use in clinical practice. Informing orthopedic surgeons about current methods of local antibiotic use is the key to the development of a modern integrated approach to the therapy of infectious complications after orthopedic surgery.
Highlights
Antibiotic Delivery From Calcium Sulfate As A Synthetic Bone Graft In A Canine Defect
One stage uncemented revision of infected total hip replacement using cancellous allograft bone impregnated with antibiotics
It is the important accompaniment to systemic antibiotics in the treatment of periprosthetic infection and osteomyelitis
Summary
Antibiotic Delivery From Calcium Sulfate As A Synthetic Bone Graft In A Canine Defect. Nanostructured Platforms for the Sustained and Local Delivery of Antibiotics in the Treatment of Osteomyelitis. Uskoković V., Hoover C., Vukomanović M., Uskoković D.P., Desai T.A. Osteogenic and Antimicrobial Nanoparticulate Calcium Phosphate and Poly-(D, L-Lactide-co-Glycolide) Powders for the Treatment of Osteomyelitis. Winkler H., Janata O., Berger C., Wein W., Georgopoulos A.
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