Abstract
The sample preparation workflow of any biological sample is the flagship of the entire analytical methodology. Currently, green analytical chemistry based on the concept of sustainability has been influencing all steps in bioanalytical method development and mostly sample preparation. Thus, new, sophisticated techniques, materials, automated arrays, and instrumental configurations have been currently introduced, driving the establishment of many novel green approaches in the field of bioanalysis. Herein, we discuss the current trends in green sample preparation before liquid chromatographic bioanalysis. • Green sample preparation approaches in the field of liquid chromatography bioanalysis are described. • Selected novel techniques are highlighted. • Innovative materials and concepts are reported. • Emphasis is given to the contribution of sample preparation in green analytical chemistry.
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