Abstract
Luteinizing hormone releasing hormone (LHRH) was 1st discovered in 1917. Since that date about 2000 analogues of the compound have been synthesized some of them agonists and some antagonists. A workshop was recently held on current treatment uses of LHRH and its analogues. Participants agreed on the efficacy of LHRH for induction of ovulation in hypogonadotrophic hypogonadal women. Several agonists have proven to be effective contraceptives. LHRH analogues have also been beneficial in the treatment of endometriosis due to their gonadal-suppressive characteristics. They have been useful in the treatment of benign gynecological disease particularly to reduce the size of fibroids. LHRH analogues have also been effective in the treatment of precocious puberty but workshop participants warned against use of them to delay puberty in an attempt to let a child grow taller. The analogues have proven useful in promoting the descent of retractile testes in children with intact hypothalamo-pituitary gonadal axis. Finally LHRH analogues have been effective in the treatment of prostatic carcinoma.
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