Abstract
Bipolar disorder is psychological illness with periodic episodes of mania and depression. Schizophrenia is a complex mental disorder identified by delusions, hallucinations, disorganized behavior, impaired cognitive ability, disorganized speech and sudden change in personality. In both the diseases quetiapine fumarate (QF) drug is worth important in today’s scenario. This review gives complete QF drug profile along with mechanism of action. Quetiapine alone is successful for acute bipolar depression and the prevention of mania/hypomania switching. Literature survey section of this review gives information about quetiapine in different dosage form. By this review one can explore the scale up of quetiapine fumarate not only with immediate release and sustained release dosage form but also with novel drug delivery system like solid lipid nanoparticle and nanostructured lipid carrier.
Highlights
2-4% of the general population suffers from bipolar I, bipolar II [1]
Schizophrenia is a complex mental disorder identified by delusions, hallucinations, impaired cognitive ability [10,11], disorganized speech [12], and sudden change in personality and behavior [13]
Exhaustive literature survey was carried out using different research, published reports pertaining to quetiapine fumarate (QF) through different databases like Google scholar, Science direct, Pub med central, Scopus etc
Summary
2-4% of the general population suffers from bipolar I, bipolar II [1]. In 2015, an estimated 17,000 people in world died by schizophrenia. Patient with bipolar disorder feels major changes in sleep, energy, thinking, behavior and highs and lows as two ‘poles’ of mood, so the name ‘bipolar disorder’. In between those poles, patient feels normal. Treatment for bipolar disorder includes drugs such as carbamazepine, lamotrigine, lithium or valproate. Sometimes drugs such as olanzapine, quetiapine, lurasidone and cariprazine and antidepressants are used. Quetiapine XR along with antidepressants is approved in the UK and US as combination therapy in patients with major depressive disorder who have not showed response to quetiapine monotherapy [20]. Brand names for QF are showed in table 3 [28]
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