Abstract
Staphylococcal cassette chromosome mec (SCCmec) typing was established in the 2000s and has been employed as a tool for the molecular epidemiology of methicillin-resistant Staphylococcus aureus, as well as the evolution investigation of Staphylococcus species. Molecular cloning and the conventional sequencing of SCCmec have been adopted to verify the presence and structure of a novel SCCmec type, while convenient PCR-based SCCmec identification methods have been used in practical settings for many years. In addition, whole-genome sequencing has been widely used, and various SCCmec and similar structures have been recently identified in various species. The current status of the SCCmec types, SCCmec subtypes, rules for nomenclature, and multiple methods for identifying SCCmec types and subtypes were summarized in this review, according to the perspective of the International Working Group on the Classification of Staphylococcal Cassette Chromosome Elements.
Highlights
Methicillin, a semisynthetic penicillin that targets beta-lactamase-producing staphylococci, was introduced to the medical field in 1960
I, II,researchers and III in the early 2000s, staphylococcal cassette chromosome mec (SCCmec) eleadopted as a molecular epidemiology tool in healthcare settings, these elements have ments have been reported by different researchers worldwide, and in addition to being been utilized in the research on the evolution of staphylococci
The discovery of SCCmec was based on the findings from multiple researchers about
Summary
Methicillin, a semisynthetic penicillin that targets beta-lactamase-producing staphylococci, was introduced to the medical field in 1960. In the same year (1960), methicillin-resistant Staphylococcus aureus (MRSA) was identified [1,2]. The excision and integration of SCCmec from/to the S. aureus. The S. aureus is is thought the to happen in and a complexed process in real clinical. For large SCCmec structures, additional processes may be necessary to pen even ininto vitro. Some in-II inversions and extra genetic fragments, which were not found in the original SCCmec versions and extra genetic fragments, which were not found in the original and and its surrounding regions of N315, suggested that SCCmec II in the latter isolate did not its surrounding regions of N315, II in the latter isolate did not directly integrate from N315, and suggested additional that processes might happen for integration. Directly integrate from N315, and additional processes might happen for integration
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