Abstract
Alginate is one of the natural polymers that are often used in drug- and protein-delivery systems. The use of alginate can provide several advantages including ease of preparation, biocompatibility, biodegradability, and nontoxicity. It can be applied to various routes of drug administration including targeted or localized drug-delivery systems. The development of alginates as a selected polymer in various delivery systems can be adjusted depending on the challenges that must be overcome by drug or proteins or the system itself. The increased effectiveness and safety of sodium alginate in the drug- or protein-delivery system are evidenced by changing the physicochemical characteristics of the drug or proteins. In this review, various routes of alginate-based drug or protein delivery, the effectivity of alginate in the stem cells, and cell encapsulation have been discussed. The recent advances in the in vivo alginate-based drug-delivery systems as well as their toxicities have also been reviewed.
Highlights
Bupivacaine release profile analyses indicated that the mode of drug delivery controlled the liposomal-alginate (LA) concentration over time and pathway analysis identified several shared and cytokine-specific molecular mediators for interleukin 6 (IL-6), prostaglandin E2 (PGE2), and TGF-β1. ese studies support the potential utility of LA for anti-inflammatory cell therapy coadministration
Spherical mesoporous aerogel microparticles were obtained for alginate, hybrid alginate/pectin, and alginate/κ-carrageenan aerogels, presenting high specific surface area and mucoadhesive properties. e microparticles were loaded with ketoprofen and quercetin. Release of both drugs from alginate/κ-carrageenan aerogel was slightly faster compared to alginate/ pectin indicating that alginate-based aerogel microparticles are potential for mucosal drug-delivery applications
Ionotropic gelation combination with freezethawing cycle cul-de-sac, increasing the bioavailability. us, some researchers worked to overcome the limitations of ocular drug delivery [137,138,139]. e chitosan-sodium alginate microspheres or other polymers encapsulating of ocular drugs have been investigated widely
Summary
Is suggested that metal ions have a significant influence on the morphology, drug encapsulation, and release profile of the chitosan-alginate hybrid polymer nanoparticles. Alginate microparticles as a carrier for protein delivery prepared by spray-drying processes have been studied for their application in nasal and pulmonary drug delivery [85,86,87] prepared inhalable alginate particles (of an average diameter 3.23 ± 0.25 μm) with a high encapsulation efficiency of 97% with the preserved structure and bioactivity of BSA. Bupivacaine release profile analyses indicated that the mode of drug delivery controlled the liposomal-alginate (LA) concentration over time and pathway analysis identified several shared and cytokine-specific molecular mediators for IL-6, PGE2, and TGF-β1. Bupivacaine release profile analyses indicated that the mode of drug delivery controlled the liposomal-alginate (LA) concentration over time and pathway analysis identified several shared and cytokine-specific molecular mediators for IL-6, PGE2, and TGF-β1. ese studies support the potential utility of LA for anti-inflammatory cell therapy coadministration
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