Current status and new progress of the preimplantation genetic testing

Abstract

With the development of assisted reproduction technique, preimplantation genetic testing (PGT) has gained more clinical application and more attention. Preimplantation genetic diagnosis (PGD), is used to avoid genetic diseases obtained from parents. With the improving of the demand of higher implantation rate and live birth rate, preimplantation genetic screening (PGS) is brought up to avoid aneuploidy, which can lead to adverse pregnancy outcomes. With the widespread of the PGT, we have to get a comprehensive understanding of the technique, so as to help patients to solve the clinical problems. In this review, we retrospect the development of the biopsy techniques and the testing techniques of PGT within nearly 30 years, and summarize the different pregnancy outcomes of blastomere biopsy and trophectoderm cells biopsy to assess the security of PGT. In addition, we analyze the current problems of PGT, and discuss its prospect in the future. Key words: Preimplantation genetic testing; Pregnancy outcomes; Testing technique; Biopsy technique