Abstract
The intestinal microbiota plays an important role in maintaining human health, and its alteration is now associated with the development of various gastrointestinal (ulcerative colitis, irritable bowel syndrome, constipation, etc.) and extraintestinal diseases, such as cancer, metabolic syndrome, neuropsychiatric diseases. In this context, it is not surprising that gut microbiota modification methods may constitute a therapy whose potential has not yet been fully investigated. In this regard, the most interesting method is thought to be fecal microbiota transplantation, which consists of the simultaneous replacement of the intestinal microbiota of a sick recipient with fecal material from a healthy donor. This review summarizes the most interesting findings on the application of fecal microbiota transplantation in gastrointestinal and extraintestinal pathologies.
Highlights
The gut microbiota has a critical function in human health, and its various disorders are associated with the development of particular diseases [1,2]
Was officially recognized for over years untilstage the first controlled began in when, for the first time in the scientific literature, American surgeon with antibiotic-associated diarrhea, as well as a rapid clinical improvement after the of useFMTBen ducted in Amsterdam, which demonstrated the high efficiency in Eisman described four patients with antibiotic-associated as well as a rapid clin of enemas with donor fecal material
Available data suggest that the application of antibiotics pre-fecal microbiota transplantation (FMT) in ulcerative colitis (UC) patients assists in the engraftment of beneficial xenomicrobiota, improving the response of treatment [29]
Summary
The gut microbiota has a critical function in human health, and its various disorders are associated with the development of particular diseases [1,2]. The modern of studies on FMT was officially recognized for over years untilstage the first controlled began in when, for the first time in the scientific literature, American surgeon with antibiotic-associated diarrhea, as well as a rapid clinical improvement after the of useFMTBen ducted in Amsterdam, which demonstrated the high efficiency in Eisman described four patients with antibiotic-associated as well as a rapid clin of enemas with donor fecal material [11]. It wasdiarrhea, not officially recognized current infectionafter oftheClostridium difficile [12].
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