Abstract
系统性红斑狼疮是一种以多系统损害和血清中出现自身抗体为特征的自身免疫性疾病。狼疮性肾炎是系统性红斑狼疮临床中最常见和最重要的并发症，儿童狼疮性肾炎的发生率更高，预后与早期诊断、积极治疗相关。目前对于狼疮性肾炎的治疗方案主要为激素和免疫抑制剂，但部分患儿不能达到临床缓解或复发，新型的靶向生物制剂有望成为难治性狼疮性肾炎新的治疗方法。.
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