Abstract
In the last decade, 3D bioprinting technology has emerged as an innovative tissue engineering approach for regenerative medicine and drug development. This article aims at providing an overview about the most commonly used bioengineered tissues, focusing on 3D bioprinted cardiac cells and how they have been utilized for drug discovery and development. The review describes that, while this field is still developing, cardiovascular research may benefit from laboratory-engineered heart tissues built of specific cell types with precise 3D architecture mimicking the native cardiac microenvironment. It also describes the role played by regulatory agencies and potential commercialization pathways for direct translation from the bench to the bedside of studies using 3D bioprinted cardiac tissues.
Highlights
This article aims at providing an overview about the lin most commonly used bioengineered tissues, focusing on 3D bioprinted cardiac cells and how they have been utilized for drug discovery and development
We developed a novel approach for the biofabrication of 3D bioprinted heart tissues using bioinks containing alginate/gelatin (Al/Ge) hydrogels and 3D cardiac spheroids (CSs) [50]
Conclusions and future directions le Emerging 3D bioprinting technologies offer therapeutic strategies to better combat heart diseases, as well as open the door for improved drug testing models in drug development. They hold much promise in ic personalized and regenerative medicine, with the opportunity of using patient-specific cells. t They uniquely allow to recapitulate the 3D cardiac tissue architecture required for functional human r myocardium
Summary
Engineered heart tissues (EHTs) have been used as a first approach to replicate the complex human heart microenvironment using patient-specific hiPSC-CMs to evaluate n mutations, drug screening and individual risk of a patient such as drug-induced side effects [15,16] Given o their three-dimensional nature, EHTs allow the measurement of cell contractility in pathophysiological conditions together with measurements of contraction kinetics, rhythm and rate, genetic and protein d analyses, and histological analyses of semi-thin, paraffin or ultrathin sections [17,18]. 3D bioprinting of cardiac tissues emerged as improved in vitro models of human heart pathophysiology [7]
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
