Abstract

Clusterin,an apoptosis-associated protein discovered a few years ago,showed hish expression inmany malignant tumors and is associated with tumorigenesis.In human,there are two elusterin isoforms.The nuclear form enhances apoptosis and the secreted form promotes cell survival.Researches on breast cancer showed that the protein and RNA expressions of clusterin were associated with the size of mammary Sland,the level of estrogen receptor and progesterone receptor,and the lymph made metastasis of cancer.There-fore,clusterin may play all important role during the tumorigenesis and development of breast cancer.Anti-sense oligo eoxy eotide against to clusterin can increase the sensitivity of breast cancer cell to some theme-therapy drugs.so clusterin may be a promising new target of breast cancer therapy. Key words: Clusterin; Breast cancer; Apoptosis

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