Current Research in Complementary & Alternative Medicine

Abstract

<h4 class="maintitle">Abstract</h4> A viral infection develops when an organism’s body is attacked by pathogenic viruses, and infectious virus particles attach to and enter susceptible cells. There are a few antiviral medicines available to manage the viral infection. The objective of this pilot clinical study was to demonstrate the preliminary evaluation on the efficacy and safety of ZingiVir-H, a herbomineral Ayurvedic preparation in hospitalized adults diagnosed with viral infection. A total of thirty patients above 18 years of age presenting with fever were enrolled from 3rd October 2019 to 28th December 2019 for conducting the pre-test and post-test clinical trial. All the patients were administered with ZingiVir-H tablet (500 mg) orally every 4th hour along with lukewarm water after light meal. The intervention was continued until the body temperature became normal. Body temperature, Complete Blood Count (CBC), Erythrocyte Sedimentation Rate (ESR), C-reactive protein (C-RP), Liver Function Test (LFT), and Renal Function Test (RFT) were recorded after treatment, first follow-up (on 7th day of discharge) and 2nd follow-up (on 30th day from first follow-up date). LFT and RFT were observed before treatment and 2nd follow-up (on 30th day from first follow-up date) and the results obtained were analyzed statistically. Repeated measurements with ANOVA recorded a significant decrease in body temperature (within an average of 4.3 days), CBC, ESR, C-RP after the intervention. The LFT and RFT parameters before and after treatments were within the recommended clinical range which established the hepato-renal safety of the ZingiVir-H in the study subjects. This study proved that ZingiVir-H is highly effective and safe in managing viral fever (jwara). <b>Keywords:</b> ZingiVir-H; Viral fever; Antipyretic; Herbo-mineral drug