Abstract
The presence of the cardiospecific cardiac troponins (cTns) I (cTnI) and T (cTnT) alongside signs or symptoms of myocardial infarction (MI) are indicative of an acute MI. As these proteins are not typically found in the sera of healthy individuals, any concentration of cTns exceeding the 99th percentile is interpreted as myocardial necrosis. Recently, new cTnI and cTnT with increased sensitivity and precision have been introduced to improve the detection and diagnosis of acute MI, the newest of which, the Elecsys® Troponin T highly sensitive assay, has demonstrated a particular advantage with high precision even in the 99th percentile. These enhanced properties are expected to increase the incidence of MI diagnoses, but currently it is not clear how to approach therapy in response to the detection of cTnT levels. The detection of elevated cTn levels alone is not sufficient for a diagnosis of acute MI, and requires an in-depth assessment of clinical presentation to determine the source and severity of myocardial damage.
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