Current realities and prospects for the arginine as a nitric oxide donor in purulent surgery

Abstract

Recently, researchers have shown an increased interest in the use of L‑arginine for surgical practice. Positive effects of this powerful nitric oxide donor, which is used in the treatment of various nosology has already been experimentally and clinically proven. At the local level, the neo‑angiogenesis processes are stimulated significantly, mechanisms of mechanical and microbial cleansing of the wound are accelerated, pro‑inflammatory cytokines are indirectly inactivated due to the powerful antihypoxic action, allowing to obtain clinically and visually clean wounds in significantly shorter terms. Detailed mechanisms of the L‑arginine effect on the purulent wounds have not been thoroughly elucidated, so promising is the study of aimed activation on wound healing mechanisms at the various stages of the wound healing process.