Abstract
Uterus transplantation (UTx) is now a possible approach for women with absolute uterine factor infertility to deliver a child, following the first successful delivery by Brännström et al. in Sweden in September 2014. This remarkable achievement attracted major attention worldwide and caused many countries to prepare for UTx, including countries in Asia. To date, three groups have performed UTx in humans in Asia, and many others are aiming for the clinical application of UTx with accumulation of basic experimental data. Therefore, it is likely that UTx will expand rapidly in Asia in the near future, although this will depend on ethical, social and religious views in each country. With this background, herein we summarize the current progress of UTx in East, Southeast and South Asia, with the purpose of increasing understanding of the current status of basic and clinical UTx research in each country and sharing progress and knowledge to ensure future development of UTx research in Asia.
Highlights
Uterus transplantation (UTx) is an alternative to gestational surrogacy and adoption for women with absolute uterine factor infertility (AUFI) to have a child
As of October 2018, more than 50 UTx procedures had been performed in Saudi Arabia, Turkey, Sweden, China, USA, Czech, Brazil, Germany, Serbia, India and Lebanon, and a total of 13 babies were born after these procedures in Sweden, USA, Brazil, Serbia and India
Gestational surrogacy is forbidden in Taiwan, and researchers need to provide an animal model report to prove sufficient training and preparation based on preclinical experiments prior to clinical application
Summary
Uterus transplantation (UTx) is an alternative to gestational surrogacy and adoption for women with absolute uterine factor infertility (AUFI) to have a child. Many other countries are aiming for clinical application of UTx, including. Uterus Transplantation (UTx) Research Groups in Asia. To the best of our knowledge, there are 13 groups currently working on UTx research in Asia: sTeovtehneibneCsthoinf ao,utrwkonoinwJlaepdagne,, athnedreoanreee1a3chgrionuIpnsdciua,rrKeonrtelya,wSoinrgkainpgoroenaUndTxTraeiwseaanrc(hFignuAresi1a):.sAeven in Chsiunma,mtwaroy ionf gJaropuapns, apnedrfoornmeineagcUhTinx rIensdeiaar,chKoisregaiv, eSniningaTpaobrle 1a.nd Taiwan (Figure 1). Fudan UniveJCirlsihniitnyUe/nsOeivbPesertsoeitptrylie/c'ssThLaneibdJeilrGiantyiUonnneciAvoerlmorsgiytyyGHSeenocesoprnaidltaHHl ooosfsppFiitutaadllan University Tongji University/Shanghai First Maternity and Infant Hospital. ChineKseeiPoeUonpilvee'srsLitiyb/eKraetiiooUn nAivrmerysitGyeHnoesrpalitHalospital Jilin UniveNrasgitoyy/Ta hDeaiJniliinReUdnCivroersssiHtyoSspecitoanl d Hospital
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