Current Progress in the Understanding of Secondary Brain Damage from Trauma and Ischemia

Abstract

Molecular and Cellular Mechanisms Disturbance of Endoplasmic Reticulum Functions - A Key Mechanism Underlying Cell Damage? * Role and Mechanisms of Secondary Mitochondrial Failure * Initiating Mechanisms Involved in the Pathobiology of Traumatically Induced Axonal Injury and Interventions Targeted at Blunting their Progression * Molecular Signals for Glial Activation: Pro- and Anti-Inflammatory Cytokines in the Injured Brain * Mechanical and Excitotoxic Lesion of Motoneurons: Effects of Neurotrophins and Ciliary Neurotrophic Factor on Survival and Regeneration News from Cerebral Ischemia Modelling of the Ischemic Penumbra * The Acute Ischemic Penumbra: Topography, Life Span, and Therapeutic Response * Environmental Influence on Gene Expression and Recovery from Cerebral Ischemia * Neuroprotective Strategies in Nature - Novel Clues for the Treatment of Stroke and Trauma * Glial Cell Swelling - Effect of Hypothermia * The Clot Thickens - Thrombolysis and Combination Therapies * Assessment of brain tissue viability under clinical Circumstances * Heparin-Mediated Extracorporeal LDL/Fibrinogen Precipitation - H.E.L.P. - In Coronary and Cerebral Ischemia Remaining Problems in Severe Head Injury Pediatric Head Injury: What is Unique and Different? * Apolipoprotein E and the Response of the Brain to Injury * System Analysis of Patient Management During the Pre- and Early Clinical Phase in Severe Head Injury * The Frequency, Antecedent Events, and Causal Relationships of Neurologic Worsening Following Severe Head Injury * Neuroprotective Effects of Riluzole in Neurotrauma Models: A Review * Challenges in Translating the Efficacy of Neuroprotective Agents in Experimental Models Into Knowledge of Clinical Benefits in Head Injured Patients