Current Progress in the Formulation and Taste-Masking Technologies for Mouth Dissolving Tablets

Abstract

Within the past one decade, mouth dissolving or fast disintegrating tablet technology has received ever-increasing demand. Mouth dissolving or fast disintegrating tablet can be defined as a solid dosage form that can disintegrate or dissolved within half-minute in the oral cavity resulting in a solution or suspension without administration of water. Mouth dissolving tablet have been formulated for pediatric, geriatric, bedridden patient or mentally ill patient and may not have access to water. Patient incompliance occurs due to bitterness of formulation. So masking the bitterness become in dispensable. To surmount this problem, several newer techniques have been developed to mask the bitter taste. Such techniques are not only masked the bitter taste but also improved the bioavailability and performance of the drug formulation. This review article focus on taste-masking techniques, conventional and advanced technologies for fast disintegrating tablet. This article also describes the properties, advantages of mouth dissolving tablets and the need for developing a better mouth dissolving tablet.