Abstract
The bases for successful antimicrobial therapy are reviewed. The impact of antimicrobics on the resident microbiota of the body and the development of resistance are considered. The phenomenon of tolerance to antimicrobics is described and a pharmacotherapeutic response is outlined. The distribution and penetration of antimicrobics is related to therapeutic needs. Finally, the choice of antimicrobics for use in obstetric and gynecologic infections is discussed.
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