Current Practice for Gastroschisis Delayed Cord Clamping versus Umbilical Cord Milking and In-Hospital Outcomes among Extremely Premature Infants in the Neonatal Research Network.

Abstract

Background: Short-term outcomes after delayed cord clamping (DCC) vs. umbilical cord milking (UCM) have not been studied outside of clinical trials. Objective: To compare in-hospital outcomes of DCC vs UCM among infants <29 weeks gestational age (GA). Design/Methods: Retrospective cohort study of infants 22 0/7-28 6/7 weeks GA born in a Eunice Kennedy Shriver NICHD Neonatal Research Network center from 1/1/16-12/31/18 exposed to DCC or UCM. Infants who had severe congenital anomalies, did not receive active treatment at delivery or were exposed to both DCC and UCM were excluded. Primary outcome: mortality or severe intraventricular hemorrhage (grade III or IV IVH) by 36 weeks postmenstrual age (PMA). Secondary outcomes: 1) mortality by 36 weeks PMA; 2) severe IVH by 36 weeks PMA; 3) any IVH or mortality by 36 weeks PMA; 4) a composite …