Abstract
Nowadays, autoimmune diseases(AD) still torment many people and they always suffer from severe symptoms and complications. However, the pathogenesis of AD is still unclear and needs more research. Also, there are shortages of treatments which can totally cure AD. This research mainly focuses on current findings of possible pathogenesis and treatments for AD by discussing and analyzing two of most famous AD: rheumatoid arthritis and systemic lupus erythematosus (SLE). This essay discusses pathogenesis of RA and SLE from three aspects: genes, immune systems and environmental factors, and then concludes current medications and therapies as well as their drawbacks. This study finds that susceptible genes, abnormal immune responses and environmental stimulation can synergistically lead to autoimmune diseases, and existing treatments are mainly composed of symptomatic treatments and modifying treatments. But each medication has its inevitable side effects. Furthermore, more research should focus on systematic treatments with fewer drawbacks in order to truly cure AD.
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