Current Opinions on Assessing F VII Activity States in Hypercoagulability and Blood Products

Abstract

This issue’s “What is happening” is focused on an area of current interest, elegantly described, by Jean Amiral and Jerard Seghatchian using newer concepts and methods to meet the multiple challenges of measuring the potency and the activation states of one of the most important clotting factors, FVII, with improved sensitivity, specificity, and precision. FVII has different activity states in various pathophysiological conditions and can be activated in a number of ways, including during the cold storage of blood or plasma [ 1 Seghatchian J. Chapter 4. Advances in the assessment of activation states of FVII in hypercoagulable state: Some epidemiological aspects and laboratory approaches for assays of factor VII and tissue factor pathway inhibitor In Vitamin K & vitamin K –dependent protein. CRC Press, 1993: 91-109 Google Scholar , 2 Miller G.J. Seghatchian J. Walter S.J. Howarth D.J. Thomson S.G. Esnouf M.P. et al. An association between the factor VII coagulant activity and thrombin activity induced by surface/cold exposure of normal human plasma. Br J Haematol. 1986; 379 Google Scholar ].