Abstract
Current methods of studying of the proliferative activity in experiment
Highlights
The substance can get into the DNA only in S-phase of the cell cycle, eliminating the variability of staining [Lehner et al, 2011, Teruaki et al, 2011]
It needs pre-injection into the tissue under study, but the exact timing and dosage of BrdU allows for evaluation of the proliferative activity in the dynamics;
Prolonged administration of BrdU can be used to assess the proliferative activity in tissues with expected low proliferative activity, since it will be detected in each molecule of the newly synthesized DNA after administration, and transmitted to daughter cells
Summary
This is necessary to select an optimal method for assessing of the proliferative activity in tissues with expected low proliferative activity. The article gives a detailed analysis of the current literature, describes various methods of studying of the proliferative activity of tissues in experiment
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