Current Medicinal Herbal Advances in the Management of Diabetic Neuropathy

Abstract

Abstract: One of the most common long-term complications of diabetes is a condition known as diabetic neuropathy. Chronic neuropathic pain is an important and debilitating disease that poses a huge healthcare challenge. Pathogenesis includes abnormalities in the blood arteries supplying the peripheral neurons, metabolic diseases such as myo-inositol depletion, and enhanced nonenzymatic glycation, among other things. Several metabolic processes are triggered when neurons are under oxidative stress, and free radicals are generated. Conventional treatments for neuropathic pain are ineffective despite the abundance of medications on the market today. The use of herbal-based natural medicines to treat hyperglycemia and its accompanying consequences is being studied extensively in addition to the commercially available formulations already on the market. Now that herbal formulations are becoming more common, researchers are paying more attention to them in medication discovery. Therefore, we conducted a comprehensive assessment of herbal medicines and plants that have been shown to have a protective effect on neuropathic pain. Here, the therapeutic effects of each plant have been documented in several neuropathic pain models in animals and humans. Furthermore, the various mechanisms for the protective effects are examined. This review's goal is to summarise the current research on herbal-based therapy for diabetic neuropathy, including pure chemicals derived from plant materials, plant extracts, and Ayurvedic formulations.