Abstract
Radiotherapy is a frequently used treatment for prostate cancer. It does not only causes the intended damage to cancer cells, but also affects healthy surrounding tissue. As a result radiation-induced urethral strictures occur in 2.2% of prostate cancer patients. Management of urethral strictures is challenging due to the presence of poor vascularized tissue for reconstruction and the proximity of the sphincter, which can impair the functional outcome. This review provides a literature overview of risk factors, diagnostics and management of radiation-induced urethral strictures.
Highlights
Current Management of Membranous Urethral Strictures Due to RadiationMarjan Waterloos 1,2†, Francisco Martins 3, Wesley Verla 2†, Luis Alex Kluth 4*† and Nicolaas Lumen 2 for the Trauma Reconstructive Urology Working Party of the European Association of Young Academic Urologists
Prostate cancer is the second most frequent cancer in men
Hughes et al examined the specimens of patients who underwent a urethroplasty for a membranous stricture and found that post-radiation specimens had a significantly decreased vascularity compared to specimens of non-radiated etiology [5]
Summary
Marjan Waterloos 1,2†, Francisco Martins 3, Wesley Verla 2†, Luis Alex Kluth 4*† and Nicolaas Lumen 2 for the Trauma Reconstructive Urology Working Party of the European Association of Young Academic Urologists. Northwestern Memorial Hospital, United States Miroslav Djordjevic, University of Belgrade, Serbia
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