Abstract
Gastrointestinal stromal tumors (GISTs) are the commonest mesenchymal tumors of the gastrointestinal tract. The tumors originate from the interstitial cells of Cajal in the gastrointestinal tract. The tumor may present with a variety of different signs and symptoms, depending on the site and pathology of the tumor. Once the diagnosis is established, an aggressive and meticulous approach is required by the treating surgeon to eradicate the disease using multimodal therapy. Treatment of GIST is primarily surgical, with an adjunctive chemotherapy in the form of tyrosinase kinase inhibitors. The stagewise surgical and medical management of GIST will be discussed in this report. A Pubmed search, with relevant terms, was performed for selecting articles, collection of data and analysis for the compilation of this report. In this article, we attempt to outline the current approaches to the successful management of GISTs. The content of this article is based on available literature in print and Internet and experience in the management and treatment of patients with GIST at our institution.
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