Abstract
Wildlife has often presented and suggested the effects of endocrine disrupting chemicals (EDCs). Animal studies have given us an important opportunity to understand the mechanisms of action of many chemicals on the endocrine system and on neurodevelopment and behaviour, and to evaluate the effects of doses, time and duration of exposure. Although results are sometimes conflicting because of confounding factors, epidemiological studies in humans suggest effects of EDCs on prenatal growth, thyroid function, glucose metabolism and obesity, puberty, fertility, and on carcinogenesis mainly through epigenetic mechanisms. This manuscript reviews the reports of a multidisciplinary national meeting on this topic.
Highlights
IntroductionResults are sometimes conflicting because of confounding factors, epidemiological studies in humans suggest effects of endocrine disrupting chemicals (EDCs) on prenatal growth, thyroid function, glucose metabolism and obesity, puberty, fertility, and on carcinogenesis mainly through epigenetic mechanisms
We provide an overview on the exposure to the main endocrine disrupting chemicals (EDCs), such as bisphenol A (BPA), Persistent organic pollutants (POPs) and Polybrominated Diphenyl Ethers (PBDEs) during intrauterine growth
Another study measured perfluorohexane sulfonate (PFHxS), Perfluorooctane Sulfonate (PFOS), perfluorooctanoic acid (PFOA), and perfluorononanoate (PFNA) in 1202 mother-child pairs; overall, PFAS concentrations were not associated with birth outcomes
Summary
Results are sometimes conflicting because of confounding factors, epidemiological studies in humans suggest effects of EDCs on prenatal growth, thyroid function, glucose metabolism and obesity, puberty, fertility, and on carcinogenesis mainly through epigenetic mechanisms. This manuscript reviews the reports of a multidisciplinary national meeting on this topic. Since the presentation of the endocrine-disrupting contaminants hypothesis [1] a new emerging science has arisen with concerns relative to the effects of endocrine disrupting contaminants on health and environment [2] This hybrid multidisciplinary science incorporates findings and methodologies from different disciplines including toxicology, endocrinology, developmental biology, molecular biology, ecology, behavioural biology and epidemiology [2].
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