Current Immunological Treatment of Recurrent Pregnancy Loss

Abstract

Recurrent pregnancy loss (RPL) is a prevalent health problem, affecting up to five percent of couples trying to establish a family. Endocrine, anatomical, infectious, and male factors were classically investigated in couples with a history of recurrent pregnancy loss, with abnormalities being identified in 56 percent of the couples. Research over the past decade has revealed increasing evidence that immunological factors are important in the evaluation of couples with a history of recurrent pregnancy loss. As we begin to understand the normal and abnormal immunological response to pregnancy, we will be able to develop more specific treatment protocols for couples with a history of unexplained recurrent pregnancy loss.