Current Hypotheses and Research Milestones in Alzheimer's Disease

Abstract

Amyloid-ss: General Aspects.- Role of A? Degrading Enzymes in Synaptic Plasticity and Neurogenesis in Alzheimer's Disease.- Pore-Forming Neurotoxin-Like Mechanism for A? Oligomer-Induced Synaptic Failure.- Interventions in Aging and Neurodegenerative Disease: Effects on Adult StemCells.- Neuronal Cytoskeleton and the Tau Hypothesis.- Tau Transgenic Mouse Models in Therapeutic Development.- What Have We Learned from the Tau Hypothesis?.- Neuronal Cytoskeleton Regulation and Neurodegeneration.- Stages of Pathological Tau-Protein Processing in Alzheimer's Disease: From Soluble Aggregations to Polymerization into Insoluble Tau-PHFs.- Plasma Membrane-Associated PHF-Core Could be the Trigger for Tau Aggregation in Alzheimer's Disease.- Oxidative Stress Hypothesis.- Neurofibrillary Tangle Formation as a Protective Response to Oxidative Stress in Alzheimer's Disease.- Neuroimmunological Hypothesis.- Inflammatory Processes Exacerbate Degenerative Neurological Disorders.- Central Nervous System Inflammation and Cholesterol Metabolism Alterations in the Pathogenesis of Alzheimer's Disease and Their Diagnostic and Therapeutic Implications.- Participation of Glial Cells in the Pathogenesis of AD: A Different View on Neuroinflammation.- Cerebrovascular Pathology and AD.- Cerebral and Cardiac Vascular Pathology in Alzheimer's Disease.- Are Amyloids Infectious?.- The Possible Link Between Herpes Simplex Virus Type 1 Infection and Neurodegeneration.- General Aspects of AD Pathogenesis.- Selective Cerebrocortical Regional, Laminar, Modular and Cellular Vulnerability and Sparing in Alzheimer's Disease: Unexploited Clues to Pathogenesis, Pathophysiology, Molecular- and Systems-Level Hypothesis Generation and Experimental Testing.- How Biochemical Pathways for Disease May be Triggered by Early-Life Events.- Biomarkers and AD.- Strategies for Alzheimer's Disease Diagnosis.- Cognitive Neurology in AD.- The Diagnosis of Dementia in Subjects with Heterogeneous Educational Levels.- Current Anti-Dementia Drugs: Hypothesis and Clinical Benefits.