Current Gene Expression Studies in Esophageal Carcinoma

Wei Guo,Yao-Guang Jiang

doi:10.2174/138920209789503888

Wei Guo, Yao-Guang Jiang

Open Access

https://doi.org/10.2174/138920209789503888

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Journal: Current Genomics	Publication Date: Dec 1, 2009
Citations: 24	License type: cc-by

Affiliation: Army Medical University, Daping Hospital

Abstract

Esophageal carcinoma is one of the deadliest cancers with highly aggressive potency, ranking as the sixth most common cancer among males and ninth most common cancer among females globally. Due to metastasis and invasion of surrounding tissues in early stage, the 5-year overall survival rate (14%) of esophageal cancer remains poor, even in comparison with the dismal survival rates (4%) from the 1970s. Numerous genes and proteins with abnormal expression and function involve in the pathogenesis of esophageal cancer, but the concrete process remains unclear. Microarray technique has been applied to investigating esophageal cancer. Many gene expression studies have been undertaken to look at the specific patterns of gene transcript levels in esophageal cancer. Human tissues and cell lines were used in these geneprofiling studies and a very valuable and interesting set of data has resulted from various microarray experiments. These expression studies have provided increased understanding of the complex pathological mechanisms involved in esophageal cancer. The eventual goal of microarray is to discover new markers for therapy and to customize therapy based on an individual tumor genetic composition. This review summarized the current state of gene expression profile studies in esophageal cancer.

Highlights

As one of the deadliest cancers with highly aggressive potency, esophageal cancer (EC) ranks as the sixth most common cancer among males and ninth most common cancer among females globally [1]
Ten of them were associated with tumor metastasis. These studies reveal how novel insights can be obtained from gene expression profiling, and highlight a group of highly interacting genes associated with metastasis in Esophageal squamous cell carcinoma (ESCC)
By comparing expression profiles of those cancer tissues, they identified 52 genes that were likely to be correlated with prognosis and possibly with resistance to anticancer drugs. These genes including H.sapiens H4/j gene, c-erbB2 and epidermal growth factor receptor. Toshimitsu and his colleagues [30] utilized cDNA microarray technology to explore the potential genes involved in acquired CDDP resistance of ESCC

Summary

Introduction

As one of the deadliest cancers with highly aggressive potency, esophageal cancer (EC) ranks as the sixth most common cancer among males and ninth most common cancer among females globally [1]. We presented associations between gene expression profiles and tumor metastasis, chemoradiotherapy resistance, immunotherapy and patient survival. By the aid of cDNA microarray analysis, Kawamata et al [13] compared the expression profiles of 9,206 genes in metastasizing human ESCC cell line T.TnAT1 to its parental non-metastasizing cell line.

Results

Conclusion