Current Drug Treatments in Alzheimer's Disease

Abstract

Alzheimer’s disease (AD) is a global common concerned neurodegenerative disease, leading to an increase in death and social problems. The pathological mechanism of AD is complicated and still unclear, and it may be affected by various epigenetic factors. So far, drugs such as cholinesterase inhibitors and glutamate receptor antagonists have been approved for clinical treatment to improve the cognitive ability of patients who suffers Alzheimer’s disease. Meanwhile, natural medicines including traditional Chinese medicine have attracted attention for their function in reducing oxidant stress, suppressing inflammation in the neuron system, and regulating gut microbiota homeostasis. The mechanism of natural medicines for AD treatment is still under investigation of the complicity of chemical ingredients in natural medicines. However, experiments and clinical trials show promising advantages of natural medicine to treat and prevent AD. The curative effect and safety of natural medicine on AD will be gradually confirmed with the development of research and clinic trials in the near future.