Current developments in homonuclear and heteronuclear J‐resolved NMR experiments

Abstract

From the first days of NMR, it is known that J‐resolved methods offer a simple spectral representation, where the J information is represented along the highly‐resolved indirect dimension. A comprehensive compilation of an entire family of new homonuclear and heteronuclear J‐resolved NMR experiments is presented. The methods are classified according to different features of pulse sequence design, involving broadband vs frequencyselective nature and homonuclear vs heteronuclear experiments. In addition, modern features in NMR pulse sequence development are also discussed. Some examples include the incorporation of broadband homonuclear decoupling techniques, the use of perfect‐echo elements to produce highly specific spin manipulations, the simultaneous measurement of multiple coupling constants and their signs, or the simultaneous measurement of scalar and residual dipolar coupling constants in a single NMR spectrum. Each reported J‐resolved experiment is discussed and illustrated with examples. As concluded in the work, it is recommended the incorporation of all these novel J‐resolved methods to the standard library of small‐molecule NMR tools to be available in any NMR lab.