Abstract
Acoustics have a wide range of uses, from noise-cancelling to ultrasonic imaging. There has been a surge in interest in developing acoustic-based approaches for biological and biomedical applications in the last decade. This review focused on the application of surface acoustic waves (SAW) based on interdigital transducers (IDT) for live-cell investigations, such as cell manipulation, cell separation, cell seeding, cell migration, cell characteristics, and cell behaviours. The approach is also known as acoustofluidic, because the SAW device is coupled with a microfluidic system that contains live cells. This article provides an overview of several forms of IDT of SAW devices on recently used cells. Conclusively, a brief viewpoint and overview of the future application of SAW techniques in live-cell investigations were presented.
Highlights
In live-cell studies, whether in vivo or in vitro, scientists and doctors are constantly inventing new approaches and methodologies to analyse specific cell characteristics and/or behaviours in multicellular or unicellular organisms, either in isolation or as part of a tissue.For example, the utilisation of biochemical, electric field, and mechanical stimuli has been extensively investigated in live-cell studies [1,2]
The results indicated that both types of focused IDT (FIDT) were capable of focusing the surface acoustic wave (SAW), whereas the FIDT with the wave surface shape exhibited better-focusing properties
Acombination of SAW device and microfluidic channel is suitable to be implemented in live-cell studies, especially in cell manipulation, cell sorting, and cell migration
Summary
In live-cell studies, whether in vivo or in vitro, scientists and doctors are constantly inventing new approaches and methodologies to analyse specific cell characteristics and/or behaviours in multicellular or unicellular organisms, either in isolation or as part of a tissue. The acoustic waves technique was firstly documented by White and Voltmer, with the introduction of the interdigitated transducer (IDT) in 1965 [9]. Unlike other devices review articles in the field of SAW that on focused only on a specific and used many article focuses the implementation of application andtypes used of many types[10,13–17], of devicesthis [10,13–17], this article focuses on the impleapplication and used many types of devices [10,13–17], this article focusesan onoverview the impleSAW techniques by using. Of mentation of SAW techniques by using IDT on various types of live cells. Future application of SAW techniques on live-cell studies was presented. 2. Scholarly work of surface acoustic waves on cellular biology from based on on lens.org. Waves onon cellular biology from based on lens.org [18]
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