Abstract
What's already known about this topic? Multiple studies have shown a strong association between abnormal levels of serum markers used for aneuploidy screening and adverse pregnancy outcomes. Despite this strong association, given a low detection rate and high false positive rate, the predictive accuracy of these biomarkers still falls short of the ideal for clinically useful screening tests. What does this study adds? This report summarizes an oral debate presented at the 20th International Conference on Prenatal Diagnosis and Therapy in Berlin, Germany, on 12 July 2016. The arguments for and against abandoning serum markers for the prediction of adverse obstetrical outcomes in women having had NIPT to screen for common aneuploidies are discussed.
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