Abstract
The therapy for acute otitis media is currently a topic in evolution. What was once a straightforward approach of matching middle ear pathogens to appropriate antibiotics has become a complex calculus that attempts to balance multiple terms such as spontaneous cure, emergence of resistance, pharmacokinetics-dynamics, antibiotic therapeutic efficacy, suppurative complications, and cost. This review highlights new developments in our understanding of this complex interaction of the issues surrounding a physician's decision to begin antibiotic therapy for acute otitis media.
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