Abstract
The relationship between sunlight and cutaneous malignancy has been recognized for almost a century. Unna (1) is generally credited with first describing this association; others followed shortly thereafter (2, 3). Hyde (3) in 1906, also recognized the role of pigmentation in the relative protection of pigmented races from skin cancer. Findlay, in 1928, was able to induce the production of skin cancer in albino mice with radiation from a quartz mercury vapor lamp (4). He also noted that application of tar to the skin of the mice shortened the exposure time necessary to induce tumors. In recent years substantial progress in understanding the pathophysiology of ultraviolet- induced skin cancer has been made. Furthermore, considerable epidemiologic and experimental evidence linking ultraviolet radiation and cutaneous malignancies has been obtained. The purpose of this review is to summarize these data.
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