Abstract
Patients with Gorham–Stout disease (GSD) present progressive destruction and resorption of bone.Typical bone-related symptoms include swelling, pain and functional impairment in the region involved.The three aspects of GSD etiopathology are osteoclasts, angiogenesis/lymphangiogenesis and osteoblast function.Multi-targeted pharmacological approach includes innovative options and represent milestones of treatment, sometimes associated with radiotherapy.Surgery is mainly used to treat complications: pathologic/impending fractures, spinal instability or deformities and chylothorax.In this narrative review, we highlight current standards in diagnosis, clinical management and therapeutic strategies.
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