Abstract
Osteosarcoma is the most common type of primary malignant bone cancer. Before the 1970's, the survival rate was dismal, and the amputation rate was nearly 100%. However, the outcome was improved after neoadjuvant chemotherapy was started in 1976. Nowadays, the formal treatment is neoadjuvant chemotherapy following wide excision with reconstruction and adjuvant chemotherapy, and several factors, such as size, serum alkaline phosphatase, tumor necrosis and metastasis, are related to the outcome. In our study. receiving previous manipvlative therapy was also an independent survival factor. A number of options that exist for limb-salvage reconstruction are classified as prosthetic and biological reconstructions, and we prefer the latter method because of better longevity and function. In Taipei Veterans General Hospital, we performed two new surgical procedures, ”transphyseal excision” and ”hemicortical excision”, which resulted in good functional outcome and no local recurrence of the tumor. As a result, the five-year survival rate was increased to 74%, and the limb salvage rate was more than 95% in our hospital, showing significant improvement. Osteosarcoma, which was known as a devastating disease in the past, now appears largely curable.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
