Abstract
In recent years, the rapid technological development and the better knowledge of genetic and molecular aspects in medicine have allowed a better approach to understand, diagnose and treat various oncological diseases. Regarding lung carcinoma, there has been a remarkable evolution from the first classifications, which were purely morphological, to the last one issued in 2015. This last classification includes histological, immunophenotypic, molecular genetics, clinical and radiological information, which allows a better evaluation and therapeutic management of these patients. In the present article, the first classifications of lung carcinoma to the last one are reviewed, and the most relevant changes and the importance of the molecular genetics findings are examined for a better clinical and therapeutic approach.
Highlights
In recent years, the rapid technological development and the better knowledge of genetic and molecular aspects in medicine have allowed a better approach to understand, diagnose and treat various oncological diseases
There has been a remarkable evolution from the first classifications, which were purely morphological, to the last one issued in 2015
Ha disminuido la frecuencia de carcinomas fuertemente asociados al tabaco, y se han incrementado los adenocarcinomas no asociados a este elemento nocivo, de forma importante, en la población femenina, lo que está ligado con mutaciones genéticas descubiertas en los últimos años . [8,9,10]
Summary
The rapid technological development and the better knowledge of genetic and molecular aspects in medicine have allowed a better approach to understand, diagnose and treat various oncological diseases. (18) Se consideraron, dentro de los tumores epiteliales, 8 tipos principales (que incluían carcinoma escamoso, adenocarcinoma, carcinoma de células pequeñas y carcinoma de células grandes), 12 subtipos, y otros subgrupos recomendados, basados en el grado de diferenciación.
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