Abstract
The past decade has witnessed numerous advances in musculoskeletal medicine that are helping to propel the field forward. From disease gene identification, to the development of CRISPR-Cas9 and its many applications to treat heritable musculoskeletal conditions, to the refinement of single-cell RNA sequencing (scRNA-seq) and its ability to characterize previously undescribed cellular populations, bench research and translational medicine are evolving at a remarkable pace. In parallel with these laboratory techniques, there has been a rapid evolution of the use of biologics within orthopedic surgery, specifically tendon healing in shoulder surgery, exemplified by the use of platelet-rich plasma, scaffolds, and stem cells to improve tendon healing in the setting of rotator cuff repair.
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