Abstract
Current Bioinformatics Challenges in Proteome Dynamics using Heavy Water-based Metabolic Labeling.
Highlights
Protein turnover in living systems has been measured with the use of stable isotope labeled tracers for over half a century [1]
Since heavy water can be administered in drinking water and does not require iv infusion, proteome dynamics studies can be conducted in free leaving organisms, including humans
The key assumptions for the heavy water-based metabolic labeling method are that the labeling of endogenous amino acids is very rapid and there is no post-synthetic labeling of a protein
Summary
Protein turnover in living systems has been measured with the use of stable isotope labeled tracers for over half a century [1]. Current Bioinformatics Challenges in Proteome Dynamics using Heavy Water-based Metabolic Labeling One of the drawbacks of the heavy water labeling method is that it cannot be applied to measure the synthesis rates of proteins with the half-life shorter than 1 hour.
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