Abstract
Diseases and damages of the ocular surface are one of the common causes of decreased vision and blindness. Dysfunction or death of limbal epithelial stem cells (LESC) plays an important role in the development of pathological processes in these conditions, which leads to the development of the limbal stem cell deficiency (LSCD). Currently, one of the methods to treat LSCD is a transplantation of cultured ex vivo LESC. The most common carriers for the cultivation of LESC in the world is the amniotic membrane (AM). However, the presence of certain disadvantages in using AM for the cultivation of LESC compels to search new types of carriers made from biological or synthetic materials. In this review, we have analyzed various types of carriers: collagen, fibrin, chitosan with gelatin, silk fibroin, keratin, contact lenses, polylactide-co-glycolide, polycaprolactone, and the possibility of their application as carriers for the LESC cultivation followed by transplantation on the ocular surface is considered.
Highlights
** Заболевания и повреждения глазной поверхности — одна из распространённых причин снижения зрения и слепоты
Current approaches to the problem of carrier selection for limbal stem cells cultivation in the treatment of limbal stem cell deficiency
For citation: Kulikov AN, Churashov SV, Chernish VF, et al Current approaches to the problem of carrier selection for limbal stem cells cultivation in the treatment of limbal stem cell deficiency
Summary
** Заболевания и повреждения глазной поверхности — одна из распространённых причин снижения зрения и слепоты. В вопросе выбора носителя для культивирования ex vivo и трансплантации ЛЭСК в настоящее время остаётся немало нерешённых задач. Сейчас ведутся исследования с материалами природного и синтетического происхождения, которые могут быть потенциальными кандидатами для использования в качестве матрицы с целью культивирования ЛЭСК: Впервые идею использования коллагена для культивации клеток роговицы развил в своей работе Geggel et al [22].
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